Everglow Face Cream — Estriol 0.3% + Hyaluronic Acid + Niacinamide

Estriol is the gentlest of the three main estrogens the body produces. Estradiol — the form used in most systemic hormone therapy — is significantly more potent. Estriol's gentler binding profile makes it well-suited for topical, localized use. Estriol sits locally on the estrogen receptors in the skin, so it doesn't tend to cause systemic effects — which is why it's the form most commonly used in prescription facial formulations.

Yes. Clinical studies have confirmed that topical facial estriol does not increase systemic serum levels of estrogen — making it suitable even for those not on menopausal hormone therapy. A HerTeleMeds clinician will review your full health history to determine whether it's appropriate for you specifically.

For many women in perimenopause, the answer is hormonal. Women lose up to 30% of skin collagen in the first five years after menopause, with 2% additional decline annually — and this hormonal shift, not chronological aging alone, drives rapid skin deterioration. Conventional moisturizers and serums address the surface; Everglow addresses the underlying mechanism.

OTC phytoestrogen creams use plant-derived compounds that loosely mimic estrogen at skin receptors — they offer mild support but operate at significantly lower concentrations and without the direct hormonal signaling that prescription estriol provides. Everglow contains 0.3% estriol — the concentration validated in clinical studies showing meaningful improvements in collagen density, wrinkle depth, and skin elasticity. Prescription strength also means your formulation is reviewed by a clinician, compounded to verified standards, and prepared by pharmacists with specific expertise in hormonal formulations.

Generally yes. Niacinamide — one of Everglow's active ingredients — works well alongside most skincare actives and actually reduces the irritation that can come with retinoid use. Estriol supports hydration, helps restore skin elasticity, and strengthens the skin barrier, particularly in hormonally impacted skin — making it a supportive base for a broader skincare routine. Discuss your full routine with your HerTeleMeds clinician at your consultation.

Barrier dysfunction is when your skin's outer protective layer stops doing its job effectively. The signs: skin that scars easily, feels persistently reactive or sensitive, develops recurring redness, or is prone to infections. Estrogen plays a direct role in lipid production and cellular repair — when levels decline, barrier function follows. Everglow's combination of estriol, hyaluronic acid, and niacinamide works specifically on this: estriol supports the repair signaling, niacinamide reinforces the barrier structure, and hyaluronic acid replenishes the moisture that a compromised barrier loses.

Most patients notice hydration and texture changes within 2–4 weeks. Visible improvements in firmness and fine lines typically develop between weeks 8–12. Maximum benefits appear after 3–6 months of regular application, as collagen turnover cycles complete and new fibers strengthen. Consistency is the variable that matters most.

Yes — and we encourage it. The neck and backs of hands are among the first areas to show estrogen-related skin changes, and they're often overlooked in skincare routines. Everglow is formulated for all three areas.